Home games in bold
| | Day | Time | | Opponent | Score | | | Record |
| January |
| * | 30 | 1:00PM | vs. | LSU-Shreveport | W-4-3 (9) | stats | | 1-0 1-0 |
| | Live Stats Listen Live |
| * | | Game 2 | vs. | LSU-Shreveport | L-1-7 | stats | | 1-1 1-1 |
| | Live Stats Listen Live |
| * | 31 | 1:00PM | vs. | LSU-Shreveport | W-9-4 | stats | | 2-1 2-1 |
| | LSUS rated No. 18 in NAIA Live Stats Listen Live |
| February |
| * | 6 | 1:00PM | vs. | Tougaloo College | W-9-2 | stats | | 3-1 3-1 |
| | Live Stats |
| * | | Game 2 | vs. | Tougaloo College | W-7-0 | stats | | 4-1 4-1 |
| | Live Stats |
| * | 7 | 1:00PM | vs. | Tougaloo College | W-11-1 (7) | stats | | 5-1 5-1 |
| | Live Stats |
| | 9 | 4:00PM | vs. | Auburn-Montgomery | L-6-9 | stats | | 5-2 |
| | AUM rated No. 23 in NAIA Live Stats |
| * | 13 | 1:00PM | @ | William Carey | RAIN | | | |
| * | | Game 2 | @ | William Carey | RAIN | | | |
| * | 14 | 1:00PM | @ | William Carey | RAIN | | | |
| * | 19 | 6:00PM | @ | Loyola University-New Orleans | W-11-2 | stats | | 6-2 6-1 |
| | Live Stats Watch Live |
| * | 20 | 1:00PM | @ | Loyola University-New Orleans | W-10-4 | stats | | 7-2 7-1 |
| * | | Game 2 | @ | Loyola University-New Orleans | W-12-7 (11) | stats | | 8-2 8-1 |
| | 23 | 1:00PM | @ | Concordia College Selma | W-3-2 | stats | | 9-2 |
| | | Game 2 | @ | Concordia College Selma | W-9-7 | stats | | 10-2 |
| | 26 | 4:00PM | vs. | Thomas University (Ga.) | L-3-5 | stats | | 10-3 |
| | Live Stats |
| | 27 | 1:00PM | vs. | Thomas University (Ga.) | L-4-6 | stats | | 10-4 |
| | Live Stats |
| | | Game 2 | vs. | Thomas University (Ga.) | L-2-5 | stats | | 10-5 |
| March |
| | 2 | 2:00PM | vs. | Selma University | W-10-5 | stats | | 11-5 |
| | Live Stats |
| | | Game 2 | vs. | Selma University | W-13-3 (6) | stats | | 12-5 |
| * | 5 | 6:00PM | @ | Belhaven University | L-4-9 | stats | | 12-6 8-2 |
| | Listen Live Live Stats |
| * | 6 | 1:00PM | @ | Belhaven University | L-4-8 | stats | | 12-7 8-3 |
| | Listen Live Live Stats |
| * | | Game 2 | @ | Belhaven University | L-7-14 | stats | | 12-8 8-4 |
| | Listen Live Live Stats |
| | 8 | 6:00PM | vs. | Lyon College | W-10-6 | stats | | 13-8 |
| | Live Stats |
| * | 12 | 6:00PM | vs. | University of Mobile | W-7-5 | stats | | 14-8 9-4 |
| | Live Stats |
| * | 13 | 1:00PM | vs. | University of Mobile | L-1-5 | stats | | 14-9 9-5 |
| | Live Stats |
| * | | Game 2 | vs. | University of Mobile | W-10-0 (8) | stats | | 15-9 10-5 |
| | Coach Frank Sims' 700th Career Win Live Stats |
| | 16 | 6:00PM | vs. | Oklahoma Wesleyan University | W-3-0 | stats | | 16-9 |
| | Live Stats |
| * | 19 | 5:00PM | @ | LSU-Shreveport | L-3-11 | stats | | 16-10 10-6 |
| | LSUS rated No. 18 in NAIA Listen Live |
| * | | Game 2 | @ | LSU-Shreveport | L-0-8 | stats | | 16-11 10-7 |
| | LSUS rated No. 18 in NAIA Listen Live |
| * | 20 | 11:00AM | @ | LSU-Shreveport | L-0-15 (7) | stats | | 16-12 10-8 |
| | LSUS rated No. 18 in NAIA Listen Live |
| | 23 | 3:00PM | vs. | Concordia College Selma | W-10-0 (5) | stats | | 17-12 |
| | Live Stats No Hitter by James Maughn |
| | | Game 2 | vs. | Concordia College Selma | W-3-1 | stats | | 18-12 |
| | Live Stats |
| * | 26 | 3:00PM | @ | William Carey | L-4-6 | stats | | 18-13 10-9 |
| | @ Stan Galle Field - Make-up of Feb. 13 Rain Out. WCU rated No. 14 in NAIA. Live Stats |
| * | | Game 2 | vs. | William Carey | W-14-9 | stats | | 19-13 11-9 |
| | WCU rated No. 14 in NAIA Live Stats |
| * | 27 | 1:00PM | vs. | William Carey | L-4-6 | stats | | 19-14 11-10 |
| | Live Stats |
| * | | Game 2 | vs. | William Carey | L-3-10 | stats | | 19-15 11-11 |
| | Live Stats |
| | 30 | 2:00PM | @ | Thomas University (Ga.) | W-13-12 | stats | | 20-15 |
| | | Game 2 | @ | Thomas University (Ga.) | L-5-6 | stats | | 20-16 |
| April |
| * | 2 | 2:00PM | @ | Tougaloo College | W-17-6 (7) | stats | | 21-16 12-11 |
| * | 3 | 1:00PM | @ | Tougaloo College | CNCL | | | |
| | Cancelled due to soggy field conditions |
| * | | Game 2 | @ | Tougaloo College | CNCL | | | |
| | Cancelled due to soggy field conditions |
| | 6 | 1:00PM | @ | Selma University | W-9-3 | stats | | 22-16 |
| | | Game 2 | @ | Selma University | W-29-17 | stats | | 23-16 |
| * | 9 | 6:00PM | vs. | Belhaven University | L-2-6 | stats | | 23-17 12-12 |
| | Live Stats Listen Live |
| * | 10 | 1:00PM | vs. | Belhaven University | L-8-17 | stats | | 23-18 12-13 |
| | Live Stats Listen Live |
| * | | Game 2 | vs. | Belhaven University | W-12-0 (7) | stats | | 24-18 13-13 |
| | Live Stats Listen Live |
| | 13 | 5:00PM | @ | Auburn-Montgomery | L-4-9 | stats | | 24-19 |
| | Live Stats |
| * | 16 | 2:00PM | @ | University of Mobile | L-5-6 | stats | | 24-20 13-14 |
| | Live Stats |
| * | 17 | 1:00PM | @ | University of Mobile | L-6-7 | stats | | 24-21 13-15 |
| | Live Stats |
| * | | Game 2 | @ | University of Mobile | W-19-10 | stats | | 25-21 14-15 |
| | Live Stats |
| * | 24 | 4:00PM | vs. | Loyola University-New Orleans | W-9-6 (7) | stats | | 26-21 15-15 |
| | Senior Day Live Stats |
| * | | Game 2 | vs. | Loyola University-New Orleans | L-4-6 (7) | stats | | 26-22 15-16 |
| | Senior Day Live Stats |
| May |
| | 6 | 11:00AM | vs. | William Carey | L-3-13 (7) | stats | | 26-23 |
| | 2010 GCAC Baseball Tournament, Smith-Wills Stadium, Jackson, Miss. - May 5-10 Live Stats |
| | 7 | 3:00PM | vs. | Loyola University-New Orleans | L-6-14 | stats | | 26-24 |
| | 2010 GCAC Baseball Tournament, Smith-Wills Stadium, Jackson, Miss. - May 5-10 Live Stats |
* Conference Event
% Exhibition/Scrimmage Event